The PHO84 gene of Saccharomyces cerevisiae encodes an inorganic phosphate transporter.
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چکیده
منابع مشابه
Enhanced arsenate uptake in Saccharomyces cerevisiae overexpressing the Pho84 phosphate transporter.
Arsenate is a major toxic constituent in arsenic-contaminated water supplies. Saccharomyces cerevisiae was engineered as a potential biosorbent for enhanced arsenate accumulation. The phosphate transporter, Pho84p, known to import arsenate, was overexpressed using a 2μ-based vector carrying PHO84 under the control of the late-phase ADH2 promoter. Arsenate uptake was then evaluated using a resti...
متن کاملKey Residues and Phosphate Release Routes in the Saccharomyces cerevisiae Pho84 Transceptor
Pho84, a major facilitator superfamily (MFS) protein, is the main high-affinity Pi transceptor in Saccharomyces cerevisiae Although transport mechanisms have been suggested for other MFS members, the key residues and molecular events driving transport by Pi:H+ symporters are unclear. The current Pho84 transport model is based on the inward-facing occluded crystal structure of the Pho84 homologu...
متن کاملPhysiological regulation of the derepressible phosphate transporter in Saccharomyces cerevisiae.
The extracellular phosphate concentration permissive for the expression of different amounts of the active high-affinity Pho84 phosphate transporter in the plasma membrane as well as the PHO84 messenger RNA levels in low-phosphate-grown Saccharomyces cerevisiae cells is very narrow and essential for a tight regulation of the transporter. The Pho84 transporter undergoes a rapid degradation once ...
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Interferon is a protein secreted by eucaryotic cells following stimulation by viruses, bacteria, and many other immunogenes. Recent medical studies indicate that interferons have effective role in the treatment of virus infections, immunodeficiency and certain types of cancer such as hairy cell leukaemia (HCL). The aim of the present study is to apply yeast strain for secreting human IFNα2b fol...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1991
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.11.6.3229